How to Regulate Your Nervous System
The nervous system is a comprehensive and continuous communication system that is made up of the central nervous system (the brain and spinal cord) and peripheral nervous system (all the other nerves in your body). The nervous system works through a complex network of neurons, neurotransmitters and stress hormones, governing everything from our thoughts and emotions to physical actions. This network of nerves is influenced by both external and internal stimuli and stressors. A “stressor” is any demand placed on the nervous system that requires physical or mental resources. Over the course of a day, you will encounter dozens, if not hundreds of stressors — for example, getting stuck in traffic, preparing for a meeting, exercising at the gym or having a conversation with a difficult family member.
Stressors — and the physiological response they elicit — are neither inherently good nor bad. The physical impact of stress is heavily influenced by our interpretation and perception of stressors. Learning to positively reframe the reflexive physiological stress response away from the negative interpretation of feeling stressed is a powerful tool to become more resilient to stress, which has numerous benefits for your immune system, hormone health, mental health and overall health and well-being.
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Learn about How to Regulate Your Nervous System
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- FAQs
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Table of Contents
- Overview
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Learn about How to Regulate Your Nervous System
- Guest Experts
- Resources
- FAQs
- Related Topics
Watch Now

Dr. Elissa Epel: Control Stress for Healthy Eating, Metabolism & Aging
In this episode, my guest is Elissa Epel, Ph.D., professor and vice chair of the department of psychiatry at the University of California San Francisco (UCSF) and the author of a new book entitled The Stress Prescription.
Learn about How to Regulate Your Nervous System
Adrenaline and Cortisol
Adrenaline (also known as epinephrine) and cortisol play crucial roles in the body’s stress response and regulation of energy levels. Adrenaline increases heart rate, breathing and other physiologic responses to prepare the body for “fight or flight.” A dysregulated nervous system can trigger a fight-or-flight response even when no real danger is present, which correlates to mental health conditions like anxiety and panic attacks and physical health issues involving hormonal imbalance or weakened immune functioning.
Cortisol mobilizes energy by converting stored carbohydrates, fats and proteins into glucose, making energy readily available for the body to use in response to stressors. Chronic stress and chronic pain can lead to prolonged high-cortisol levels, which can increase cravings for sugary and fatty foods and contribute to high blood pressure, cognitive burnout and other health issues.
Just as exposure to stress isn’t inherently good or bad, the effects of these stress hormones can be beneficial or detrimental to health, depending on regulation and timing. You can leverage adrenaline and cortisol to your benefit to enhance performance and resilience by using short-term stressors like cold water exposure or intense exercise to increase energy, alertness and focus before a cognitively demanding task.
Tool Kit 3: Increase Epinephrine (Adrenaline) & Alertness
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Adrenaline & Cortisol
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Tool: Sunlight, Sauna & Cortisol Reduction
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Protocols for Stress
Regulating the nervous system is about enhancing one’s ability to manage stress and emotions effectively, and involves managing the autonomic nervous system (ANS) and its reflexive stress response, which is responsible for controlling bodily functions like heart rate, digestion and respiratory rate. Adopting a mindset that views stress as enhancing — rather than debilitating — can positively influence your body’s response to stressors. Studies suggest that when you perceive stress as beneficial, you are more likely to handle stressful situations better.
There are several protocols that can be incorporated into your daily routine to regulate your nervous system, such as exercise, physiological sighs and meditation. These protocols can be used in real time when experiencing a stress response to return your nervous system to a state of alert yet calm. You can build long-term resilience to stress by practicing these same protocols during exposure to controlled stressors (like cold exposure, intense exercise or exposure therapy). Overcoming small stressors can serve as a reward system, reinforcing your sense of accomplishment and resilience, preparing you for larger challenges in the future.
Pillar #6: Stress Control; Physiological Sigh
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Breathwork
Breathing plays a crucial role in regulating the nervous system. It serves as a bridge between the conscious and subconscious control of your body, allowing you to self-regulate your physiological state by managing your breath. Prolonged periods of sitting and focusing on a computer screen throughout the day can lead to shallow breathing patterns, which can negatively impact energy levels and cause feelings of anxiety. Taking breaks to practice deep breathing can reenergize the mind and body.
There are specific techniques like the physiological sigh (also referred to as cyclic sighing when repeated for multiple breaths), which can rapidly reduce stress and calm down the nervous system. This involves taking two inhales through the nose followed by a long exhale through the mouth, using the interaction between the sympathetic nervous system (arousing) and parasympathetic nervous system (calming) branches of the autonomic nervous system to control your heart rate and induce calmness. Additionally, the rhythm of your breathing significantly affects heart rate — longer exhales generally lower heart rate and promote relaxation, while quick, frequent inhales (used in the Wim Hof Method) increases heart rate and alertness.
Breathing exercises are powerful tools for nervous system regulation as they allow you to modulate physical and emotional states through conscious breath control.
Protocols 2, 3, 4: Control Heart Rate With Breathing
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Tool: Shifting Stress to Challenge Response, “Stress Shields”
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Tool 6: Down-Regulation Breathing & Recovery
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Resilience and the Benefits of Stress
In neuroscience, the distinction between “good” stress and “bad” stress lies in how it affects us psychologically and physiologically, depending on the nature of the stressor and one’s subjective perception of it. Good stress, often referred to as “eustress,” occurs when a stressful experience is seen as a manageable opportunity for growth and is energizing and motivating — even if not especially enjoyable. Bad stress, or "distress," occurs when a stressor is seen as overwhelming and triggers a threat response.
On the podcast, professor and psychology researcher Dr. Alia Crum, discussed the research on “physiological toughening,” which suggests that stress can activate anabolic hormones, which helps build muscles and neurons, thereby facilitating growth and learning. Her studies further indicate that viewing stress as a challenge — rather than a threat — can result in enhanced performance and improved sense of well-being.
Of course, there are major life events that are inherently distressing, like job loss or the death of a loved one. Stress becomes harmful to your health when it is chronic and felt over extended periods without relief, so in these situations, finding activities for self-care that can provide even temporary stress relief can give your nervous system time to return to homeostasis — whether it’s a brief mindfulness meditation, walk in nature or spending time with people you care about.
Tool: Raise Stress Threshold, Deliberate Cold Exposure
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Stress-Is-Enhancing vs Stress-Is-Debilitating Mindsets
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Guest Experts
Resources
Articles & Research Papers
- Cardiac vagal control as a marker of emotion regulation in healthy adults: A review (Biological Psychology)
- Brief structured respiration practices enhance mood and reduce physiological arousal (Cell Reports Medicine)
- Stress, Mindsets, and Success in Navy SEALs Special Warfare Training (Frontiers in Psychology)
- Rethinking stress: The role of mindsets in determining the stress response (Journal of Personality and Social Psychology)
- A central master driver of psychosocial stress responses in the rat (Science)
- A synergistic mindsets intervention protects adolescents from stress (Nature)
- Stress and telomere shortening: Insights from cellular mechanisms (Ageing Research Reviews)
- Embodying Psychological Thriving: Physical Thriving in Response to Stress (Journal of Social Issues)
Books & Other Resources
- Good Anxiety: Harnessing the Power of the Most Misunderstood Emotion (Book by Dr. Wendy Suzuki)
- Toolkit for Changing Stress Mindsets (Stanford SPARQTools)
Note: Books listed here may include Amazon affiliate links, which provide a small commission to support the podcast at no additional cost to you